American Gut

by American Gut Project (UC San Diego)

Organization campaign Keep it all San Diego, CA, US

World's largest open-source science project to understand the microbial diversity of the Human Gut. Learn which microbes live in your gut, skin & mouth. Join over 10,000 people, get a home sampling kit and support the research. See the whole story

$962,602

Raised so far

6293

Contributors

The Human Microbiome Project and other microbiome projects worldwide have laid an important foundation for understanding the trillions of microbes that inhabits each of our bodies. However, opportunities for the public to get involved in such research has been limited. Now, American Gut gives you an opportunity to join this research project and to compare the microbes in your gut to those in the guts of thousands of other people in the US and around the world. American Gut is a project built on open-source, open-access principles. Our data are for the good of understanding and will be shared both with participants and with other scientists. Our experience has been that our best ideas and work come when we involve people in as many steps of our work as possible, be they scientists, educators, roofers, ultra-marathon runners or corporate leaders. Everyone has something to offer, whether their sample, their hypotheses, their analyses or their dog (yes, their dog, we will get back to that). The more we can understand the complex microbial ecosystems on which we depend, the more everyone will benefit.

A few important points to remember before joining this research project:

1. Note your de-identified information will be part of a research study and will be made available in a publicly available research database. That is, any personal information that might easily identify who you are will be removed before being placed in the public database.

2. It’s simple to join: send $99 to the project. Once you receive your kit(s), you will be required to a) sign an online consent form and b) fill out an online questionnaire. If either are not signed or filled out, we cannot perform the microbiome analysis. Your payment will only be refunded if requested explicitly. Remember, the online "consent and questionnaire" forms are part of the American Gut portal NOT something you sign with Fundrazr when you join the research project. If you decide that you no longer wish to continue in this study, you will be requested to contact the American Gut Project helpline (info@americangut.org) to inform us of your intent to withdraw. If your sample has not been processed you may request a refund which will be processed through the site where you contributed to the project (PayPal).

3. The consent forms are maintained on the participant website; details are included in your kit. To sign the consent form, you must agree to use an electronic format for your signature in accordance with the United States' eSIGN Act and California's UETA Act. You have the right to obtain the electronic record in a non-electronic form.

If you live in the UK or anywhere else in Europe, visit our sister site British Gut to join this research project.

1. See how your microbiome compares to others and learn how your diet & lifestyle may shape your gut microbiome. Thousands have enrolled already.
2. International participants welcome. However, please add $25 to your payment for shipping kits. Also be aware that you will need to FEDX your sample back to University of California-San Diego. This could get pricey. So please make note of this before joining the study. (Folks in the UK click here)
3. Our team has sequenced thousands of samples from all over the world
4. Once you sign up, you will receive a swab kit in the mail within 4-6 weeks.
5. Visit us to get more details and learn how you can join this important study. http://humanfoodproject.com/americangut/

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Perks

Claim these great perks with your contribution.

  • 6 claimed
Get your kits faster with two day USPS Priority Shipping by adding this perk to your order. Only valid for US orders.
  • 55 claimed
This Perk is for the parent of a participant enrolled in American Gut's "ASD-Cohort." Note the Perk is for ONE swab/kit. If both parents want to enroll, multiple by 2. The reduced Perk rate is made possible by a generous grant. If you have an ASD child and want to have them considered for a FREE gut microbiota analysis, please email mcdonadt [AT] colorado.edu
  • 3332 claimed
The ribosome is the factory that makes proteins and is found in all cells, and fascinatingly it is mostly made of RNA. One RNA subunit, called the 16S rRNA, is especially effective as a barcode for understanding which microbes (specifically, bacteria and archaea) are found in a given sample. This PERK includes DNA extraction and 16S rRNA sequencing of one stool sample (or an oral or skin sample – the same kit works for any of these), and shows which bacteria and archaea were present in that sample along with how much of each kind. You be able to view, download and print a high-resolution certificate suitable for framing of your results and access to more detailed taxa report of your results - which can be viewed online and downloaded into Excel.
  • 360 claimed
This is two kits: 1 for you and one for someone from either Africa, South America or Asia. Your support of this PERK will allow us to sequence more people from around the world as part of our ongoing research. DNA extraction and 16S rRNA sequencing of one stool sample (or an oral or skin sample - the same kit works for any of these).
  • 1209 claimed
DNA extraction and 16S rRNA sequencing of two stool samples, e.g. couples, father/son, mother/daughter, you and your dog (or, one stool and say an oral sample – is up to you – mix and match how you like). You be able to view, download and print a high-resolution certificate suitable for framing of your results and access to more detailed taxa report of your results - which can be viewed online and downloaded into Excel.
  • 259 claimed
DNA extraction and 16S rRNA sequencing of three stool samples if there are three of you in your home (or, two stools and say an oral sample or one stool, one oral and one skin – is up to you – mix and match how you like). You be able to view, download and print a high-resolution certificate suitable for framing of your results and access to more detailed taxa report of your results - which can be viewed online and downloaded into Excel.
  • 270 claimed
DNA extraction and 16S rRNA sequencing of four stool samples if there are four of you in your home (or, two stools and say two oral samples or two stools and one oral and one skin). It’s up to you – mix and match, you get the idea. You be able to view, download and print a high-resolution certificate suitable for framing of your results and access to more detailed taxa report of your results - which can be viewed online and downloaded into Excel.
  • 18 claimed
(you heard us!) DNA extraction and 16S rRNA sequencing of up to 7 samples. Collect a stool sample every day of the week and send to us along with your detailed dietary information etc. See how your New Year’s resolution changed your gut microbes! Or see how much those antibiotics you took for a sniffle affected you. Or your travel to Mexico, where you drank the water. Our microbes change a lot over our lives, but what affects them the most remains largely a mystery.
  • 5 claimed
Shallow shotgun metagenomic analysis of up to four fecal samples (furry family members also ok), including mapping to reference genomes and comparing profiles of genetic similarities and differences among different family members. Shallow shotgun metagenomics means instead of using the 16S rRNA as a marker gene, we fragment all the DNA in the sample, grind it up, sequence it in small pieces, and try to figure out what it is afterwards. The bad news is that much of this information is still mysterious because we don’t know the complete genomes of most of the microbes in there, but the good news is that you can get an insight into the gene functions, not just which microbes are there.
  • 13 claimed
Deeper shotgun metagenome and virome characterization of one sample, plus additional marker gene sequencing (16S rRNA, 18S rRNA and ITS, for you sequencing wonks) to characterize not just the bacteria but also the viruses, microbial eukaryotes (like giardia), and fungi in your gut. This PERK allows you to see everything, not just the bacteria, that’s in there. 18S rRNA is similar to 16S rRNA but for eukaryotes (like us); ITS is the internally transcribed spacer, a very fast-evolving region that lets you see very detailed information about the species that are there.
  • 3 claimed
Deeper shotgun metagenomic characterization of up to 7 stool samples, providing an analysis of the variability of functions over time. This could be a great opportunity to see if fasting or extreme diet has an effect on your microbes! We would recommend doing this as a timeseries, either daily, weekly or monthly, to track how you’re doing when you travel or when you change your diet (those New Year’s resolutions again!)
  • 0 claimed
Deep characterization of a single stool sample by shotgun metagenomics, includes best-effort attempt to assemble one or more bacterial genomes out of your gut. You will get a framed poster of the assembled genome showing differences to its close relatives. Only serious need inquire – please email info@amergicangut.org to express your interest before signing up for this one.
  • 1 claimed
RNA expression profiling of up to five samples, which tells you not only who is in your gut but what genes they have turned on. Ideal for seeing responses to probiotic yogurt or other short-term dietary changes! RNA, or ribonucleic acid, is primarily used as the messenger in the cell transmitting DNA to protein: looking at the RNA therefore tells you which genes are switched on, which often happens at much faster time scales than change in the genes or species that are in your gut but can have huge functional consequences in terms of producing metabolites that could affect health. Only serious need inquire – please email info@amergicangut.org to express your interest before signing up for this one.
  • 0 claimed
Be among the first in the world to get the most detailed map of your gut microbiome and help us push the state-of-the-art in high-throughput sequence technology of microbial communities. We will perform ultra-deep sequencing of your microbiome sample aimed at generating as many individual bacterial genomes as possible (we can’t tell you how because the details of the technique are still under wraps prior to publication). Only serious need inquire – please email info@amergicangut.org to express your interest before signing up for this one.

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